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M94A3175.TXT
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Document 3175
DOCN M94A3175
TI Genetic analyses of HTLV-I from India and newly identified endemic Loci,
Iranian Mashhad and Russia.
DT 9412
AU Yamashita M; Syrtsev A; Achiron A; Shohat B; Gurtsevitch V; Ishida T;
Yamamoto N; Takehisa J; Igarashi T; Ibuki K; et al; Inst. Virus Res.,
Kyoto Univ., Japan.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):136 (abstract no. PA0162). Unique
Identifier : AIDSLINE ICA10/94369400
AB OBJECTIVE: Recently, Mashhadi Jews immigrated from Iran to Israel and
people in some part of Russia such as Saharin and Turkmenistan were
reported to have high prevalences of HTLV-I. To clarify phylogenetic
relations, HTLV-I newly isolated in these loci and India were compared
with others reported previously. METHODS: A part of LTR sequences was
amplified from DNA of seropositive subjects by PCR. Their proviral DNA
were sequenced and phylogenetically analyzed. RESULTS: Phylogenetic
analysis evidently showed that both Iranian jewish and Indian HTLV-I
were included to subtype A of cosmopolitan type, which consists of those
from Caribbean basin, Japan and South America. The isolates of Iran
formed a distinct cluster in subtype A, while Indian isolates did not
cluster. Sequence analysis of Russian samples are in progress and will
be presented. DISCUSSION AND CONCLUSIONS: The isolates of Iran, India,
Japan, Caribbean Basin and South America have the definite relation each
other and subtype A is spread over a large area. This finding is
interesting in elucidating the origin and evolution of HTLV-I.
DE Cluster Analysis Emigration and Immigration Evolution Human
HTLV-I/*GENETICS/*ISOLATION & PURIF HTLV-I
Infections/*EPIDEMIOLOGY/MICROBIOLOGY India/EPIDEMIOLOGY
Iran/ETHNOLOGY/EPIDEMIOLOGY Israel/EPIDEMIOLOGY Jews Prevalence
*Repetitive Sequences, Nucleic Acid Russia/EPIDEMIOLOGY MEETING
ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).